GDF-15, soluble ST2 and Troponin-I: Biomarkers of Subclinical Vascular Disease?
نویسندگان
چکیده
منابع مشابه
GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease
BACKGROUND Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations between GDF-15 and subclinical coronary atherosclerosis, assessed by coronary artery calcium (CAC) score, in COPD subjects free of clinical cardiovasc...
متن کاملBiomarkers of cardiovascular stress and subclinical atherosclerosis in the community.
BACKGROUND Biomarkers of cardiovascular stress have been associated with incident cardiovascular outcomes. Their relations with measures of subclinical atherosclerosis, as assessed by carotid intima-media thickness, have not been well described. METHODS We measured plasma growth differentiation factor-15 (GDF-15), soluble ST2 (sST2), and high-sensitivity troponin I (hsTnI) in 3111 Framingham ...
متن کاملAssociations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.
BACKGROUND AND PURPOSE Growth differentiation factor-15 (GDF-15) and soluble (s)ST2 are markers of cardiac and vascular stress. We investigated the associations between circulating concentrations of these biomarkers and incident stroke and subclinical vascular brain injury in a sample from the Framingham Offspring cohort. METHODS We followed 3374 stroke- and dementia-free individuals (mean ag...
متن کاملGDF 15 ( growth differentiation factor 15 )
The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
متن کاملSerum troponin I as an indicator of myocarditis in lambs affected with foot and mouth disease
Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hooved livestock and wildlife results to relatively high mortality in young animals. Despite the numerous reports of FMD-related death in neonates, there is little data available on various aspects of FMD in lambs. This report describes myocarditis associated with FMD in five, one week to three months old lambs. The lam...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2016
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2016.02.008